Researchers at Osaka University uncover key mechanistic details that allow cholesterol to be transported within cells — ScienceDaily

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The findings, published in The Journal of Cell Biology, may serve as a jumping-off point for further studies in this newly-uncovered transfer system for cholesterol.

“Our study suggests that RELCH is a key linkage protein that allows cholesterol to be transferred across Rab11-containing recycling endosomes to OSBP-containing Golgi membranes,” lead investigator Akihiro Harada concludes. “Identifying the Rab11-RELCH-OSBP complex is a major step forward in understanding how non-vesicular transport operates. We believe the findings will eventually help drive the discovery process for treatments of cholesterol-related metabolic disorders involving this unique transport pathway.”

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