Now Stanford neurologist Thomas Rando, MD, PhD, and former postdoctoral scholar Marco Quarta, PhD, have outlined a three-part strategy that, at the least in mice, helps muscle stem cells develop new muscle tissue. They revealed their results in the present day in Nature Communications.
As Rando, who also directs Stanford’s Glenn Center for the Biology of Aging, described to me in a telephone conversation:
Massive, traumatic wounds like those skilled by some veterans are very troublesome to deal with clinically. Often the first focus is on repairing injury to the skin and bone. We haven’t been capable of do a lot to encourage regrowth of the missing muscle. Injecting muscle stem cells doesn’t work because they don’t perform nicely in a vacuum.
So what to do? Rando and Quarta constructed on earlier work during which they showed that muscle stem cells are happiest once they feel at house. In their previous research, they mimicked the stem cells’ setting by developing artificial muscle fibers upon which to develop the stem cells in the laboratory. In this new research, they created a three-dimensional construction referred to as a bioscaffold — principally a muscle fiber by which the naturally occurring cells are removed to go away behind just the extracellular matrix. Muscle stem cells seeded upon the matrix snuggled in and, when transplanted into mice, began to switch missing muscle tissue. But then they took the “residence away from residence” concept one step additional.