Different cognitive effects of dextromethorphan and psilocybin observed in new study

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New research helps identify some of the differences between the cognitive effects of classical hallucinogens and dissociative hallucinogens. The study was published in the journal Psychopharmacology.

“Both classic (serotonergic) and dissociative (glutamatergic, NMDA-mediated) hallucinogens are being investigated as potential novel, fast-acting therapeutics for mood disorders and substance use disorders,” said study author Frederick Barrett of the Johns Hopkins University School of Medicine.

“Also, a recent study suggested that dissociative hallucinogens may share a number of subjective effects with classic hallucinogens. However, these drugs have never been directly compared on their acute effects on a wide number of measures of cognition.

“The study was conducted to directly compare classic and dissociative hallucinogens and their effects on cognition,” Barrett said.

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