Brain development influenced by the immune system – UQ News

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“Our findings mean we should be very careful when targeting the complement system to dampen inflammation during pregnancy, as there might be associated risk from treating pregnant women for inflammation.

“Either through infection or medication, complement factor activity has the potential to throw off that balance and therefore have consequences in adulthood.

The findings also highlight new and unexpected potential causes for developmental brain diseases as well as risk factors for mental illness.

“Local disruption of brain development by complement factors can also result in abnormal networks, neural positions or what type of neuron the stem cell becomes,” Dr Coulthard said.

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