In the two years, April 2018-March 2020:
- Will further develop the striatal circuit model based on compartmental models with interneurons, MSNs – D1 and D2 and the input from cortex and thalamus, considering the circuits involving both action-selection and evaluation.
- Modulation of cellular electrophysiology by dopamine and acetylcholine, and its influence on the striatal function. Study of the effects of neuromodulators on ion channels and synapses in different cell types; and matching the net effects of the striatal microcircuit to the experimental data.
- Regulation of the midbrain dopamine system by the striatum via habenula (to be initiated). Closing the control loop by simulating dynamic response of the striatal microcircuit to varying dopamine release.
- Interaction of different basal ganglia nuclei will be studied; the results will be progressively added to the system at the pace of acquisition of the data and knowledge.
Who is Involved
Building a model of the basal ganglia from sparse, fragmented data and improving our understanding of the basal ganglia function requires a critical mass of experimental data and expertise.
The following people and their teams are driving this effort:
Sten Grillner (Professor), Department of Neurophysiology, Karolinska Institute, Sweden
Alexander Kozlov (PhD), Science for Life Laboratory, KTH Royal Institute of Technology, Sweden
Johannes Hjorth (PhD), Science for Life Laboratory, KTH Royal Institute of Technology, Sweden